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Dr. Johannes ZUBER Research Group Leader, IMP - Research Institute of Molecular Pathology, Vienna


  Clinical training in general oncology, hematology and hemostaseology, high-dose chemotherapy, stem-cell transplantation and intensive care medicine
2001-2005 Clinical Internship & Residency (Arzt im Praktikum & Assistenzarzt) in Hematology and Oncology, Charité University Hospital, Berlin
  Development of genetically engineered leukemia mouse models; studies on mechanisms in leukemogenesis and drug resistance; RNAi technology (new vector systems, RNAi Sensor assay, in-vivo RNAi screening, custom shRNA libraries)
2005-2008 Postdoctoral Research Fellow, Laboratory of Scott W. Lowe, PhD Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
  In-vivo RNAi studies in leukemia mouse models and transgenic RNAi models. Multiplexed negative-selection RNAi screening, RNAi-based in-vivo validation of candidate therapeutic targets. Chromatin regulators in leukemia maintenance
2009-2010 Clinical Research Fellow, Cold Spring Harbor Laboratory, New York
since 2011 Research Group Leader, IMP - Research Institute of Molecular Pathology, Vienna


Zuber J*, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, Brown P, Valent P, Bradner JE, Lowe SW, Vakoc CR: RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia, Nature. 2011;478(7370):524-528. doi: 10.1038/nature10334
Zuber J*, McJunkin K*, Fellmann C, Dow LE, Taylor MJ, Hannon GJ, Lowe SW: Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi, Nature Biotechnology. 2011;29(1):79-83. doi: 10.1038/nbt.1720
Zuber J*, Rappaport AR*, Luo W, Wang E, Chen C, Vaseva AV, Shi J, Weissmueller S, Fellmann C, Taylor MJ, Weissenboeck M, Graeber TG, Kogan SC, Vakoc CR, Lowe SW: An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance, Genes & Development. 2011;25(15):1628-1640. doi: 10.1101/gad.17269211
Zuber J, Radtke I, Pardee TS, Zhao Z, Rappaport AR, Luo W, McCurrach ME, Yang MM, Dolan ME, Kogan SC, Downing JR, Lowe SW: Mouse models of human AML accurately predict chemotherapy response, Genes & Development


Dr. med. degree awarded with summa cum laude, 2003
Research Fellowship of the DFG (Deutsche Forschungsgemeindschaft), 2006-2008
Ambassador Felix Schnyder Grant (Lauri Strauss Leukemia Foundation), 2006-2007
CSHL Andrew Seligson Memorial Clinical Research Fellowship, 2009-2010