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Ph.D. Richard A. ENGH Professor of Structural Chemistry; Group Leader, Research Unit "Structure determination", The Norwegian Structural Biology Centre, University of Tromsø


1981 Augustana College, South Dakota, B.A.
1982-1987 University of Chicago; M.S., Ph.D. thesis on Molecular dynamics studies and laser spectroscopy
1988-1992 Postdoctoral fellow with R. Huber, MPI Biochemistry
1992-2006 Coordination of structure based drug design collaboration MPI with Boehringer Mannheim GmbH and Roche Diagnostics GmbH: Technology Director Structural Analysis and Head of Crystallography


(Selected from some 100 publications and patents:)
FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro, N. von Bubnoff, R.A.Engh, E.Aberg, J.Sänger, C,Peschel, J.Duyster, Canc. Res. (2009), 69, 3032-3041.
Protein kinase inhibitors highlight the complexities of drug target noncovalent interactions; R. Engh, Biotechnol. & Biotechnol. Eq. (2008), 22, 773-777.
Surrogate approaches to AGC-kinase inhibition; D.Bossemeyer, M.Gassel, S.Bonn, C.B.Breitenlechner & R.A.Engh; Abstracts of Papers, 231st ACS National Meeting, Atlanta, GA, USA, March 26-30, 2006.
Crystallography for protein kinase drug design: PKA and SRC case studies; C.B.Breitenlechner, D.Bossemeyer & R.A.Engh; Biochim. Biophys. Acta, Prot. & Proteom. (2005), 1754, 38-49.
Crystal structures of active SRC kinase domain complexes, C.B.Breitenlechner, N.A.Kairies, K.Honold, S.Scheiblich, H.Koll, E.Greiter, S.Koch, W.Schäfer, R.Huber, R.A.Engh; J. Mol. Biol. (2005), 353, 222-231.
Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT); M.Gaßel, C.Breitenlechner, P.Rüger, U.Jucknischke, T.Schneider, V.Kinzel, R.Huber, D.Bossemeyer & R.A.Engh; J. Mol. Biol. (2003) 329; 1021-1034.
Structural aspects of protein kinase control Role of conformational flexibility; R.A.Engh & D. Bossemeyer; Pharmacology and Therapeutics (2002) 93; 99-111.
Structure Quality and Target Parameters; R.A.Engh & R.Huber; International Tables for Crystallography, Volume F: Crystallography of Biological Macromolecules, 2001; (M. Rossmann & E. Arnold, eds.), Kluwer Academic Publishers, Dordrecht, 382-392.
New Enzyme Lineages by Subdomain Shuffling; K.-P.Hopfner, E.Kopetzki, G.-B.Kresse, R.Huber & R.A.Engh; PNAS (1998) 95; 9813-9818.
Enzyme Flexibility, Solvent and 'Weak' Interactions Characterize Thrombin-Ligand Interactions: Implications for Drug Design; R.A.Engh, H.Brandstetter, G.Sucher, A.Eichinger, U.Baumann, W.Bode, R.Huber, T.Poll, R.Rudolph & W. von der Saal; Structure (1996) 4; 1353-1362.


National Merit Scholarship
Fulbright-Hays Scholar
McCormick Fellowship
National Science Foundation Fellowships
Research Grant Awards in Functional Genomics, Chemistry, Cancer Research